Medicines that interact with Fioricet may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Fioricet. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.
Common medications that may interact with Fioricet include:
acetaminophen
antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline)
anticonvulsants, such as carbamazepine, divalproex, lamotrigine, phenytoin, phenobarbital, or primidone antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone) any medication that may cause drowsiness, such as amphetamines, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, fentanyl, or morphine)
atomoxetine
azelastine
barbiturates
buprenorphine
cannabis
cyclosporine
dextromethorphan
duloxetine
heart medications such as diltiazem or verapamil
HIV medications such as ritonavir
migraine medications, such as ergotamine or dihydroergotamine
muscle relaxants, such as cyclobenzaprine
naltrexone
other medications that contain acetaminophen or an opioid either in combination or as the sole ingredient
pentazocine
prilocaine
rifampin
sodium oxybate
tamsulosin
tramadol
warfarin.
Avoid drinking alcohol or taking illegal or recreational drugs while taking Fioricet because it may enhance the hepatotoxic effect of acetaminophen.
Note that this list is not all-inclusive and includes only common medications that may interact with Fioricet. You should refer to the prescribing information for Fioricet for a complete list of interactions.